Our lysis buffer is engineered to extract not just small and medium proteins, but also large and complex proteins, including those exceeding 150 kDa, all while preserving their structural integrity. Sonication is not required, thereby preventing protein fragmentation.

Engineered for efficiency, our lysis buffer eliminates the need for adding protease inhibitors or post-translational modification (PTM) protectants such as phosphatase inhibitors. With just two simple reagents and a streamlined protocol, you can reliably preserve protein integrity and all associated PTMs.

This versatile lysis buffer is optimized for use with mammalian tissues and cells. It has demonstrated exceptional performance in protein extraction from adipose tissue, making it an ideal solution for challenging sample types. Our formulation ensures broad compatibility and consistently high-quality protein yields.